Dietary Protein, Cholesterol and Atherosclerosis:
A Review of the Early History
The first purely nutritional investigation
into experimental atherosclerosis was carried out by
Ignatowski in 1908. Believing that a toxic metabolite
of animal protein led to atherosclerosis, he fed meat to
adult rabbits and milk and egg yolk to weanling rabbits
and caused atherosclerosis. For the next two decades
experimental efforts from many laboratories were di
rected at determining which, if any, animal protein was
the most atherogenic. The discovery in 1912 that di
etary cholesterol per se was atherogenic turned atten
tion to fat and cholesterol, eclipsing work on dietary
protein.
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